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Efficacy & Safety ProfileEfficacy & Safety ProfileAcutePivotal TrialLong-Term Safety StudyTriptan Unsuitable StudyPreventivePivotal TrialPivotal Open-Label Safety ExtensionPrior Inadequate Response StudyCHALLENGE-MIG StudyDosingAbout NurtecAbout NurtecMechanism of ActionPatient ProfilesAccess & SupportAccess &
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For the acute treatment of migraine with or without aura and the preventive treatment of episodic migraine in adults1

Dosing

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Dosing

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Nurtec ODT is dosed in 2 different ways to treat or help prevent migraine1

Acute
One 75 mg ODT, as needed, for the acute treatment of migraine with or without aura in adults.1

The maximum dose for acute treatment is one 75 mg tablet in 24 hours.1

75 mg Nurtec ODT PRN1

Include refills1

Disp or qty1:
8 tablets (1 blister pack) or
16 tablets (2 blister packs)

Preventive
One 75 mg Nurtec ODT every other day for the preventive treatment of episodic migraine in adults.1

No titration and no loading dose necessary.1

75 mg Nurtec ODT EOD1

Include refills1

Disp or qty1:
16 tablets (2 blister packs)

The safety of using more than 18 doses in a 30-day period has not been established.1

Patients can take Nurtec ODT on the go1

No water needed and can be taken with or without food1

The ODT formulation may be helpful for patients who experience nausea and vomiting2

Tmax of 1.5 hours and elimination half-life of ~11 hours1*

EOD=every other day; PRN=as needed.*Store Nurtec ODT at controlled room temperature, 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F).1Additional considerations for your patients who may benefit from Nurtec ODT
  • No restrictions for patients taking oral contraceptives¹
  • ~11-hour half-life may facilitate rapid reduction or elimination of drug exposure, which may be helpful in case of an adverse event or when considering family planning¹˒³
  •  Lactation study demonstrated low breast milk transfer, with a relative infant dose of <1% of the maternal weight-adjusted dose and a milk-to-plasma ratio of 0.201¹ 
  • There are no data on the effects of rimegepant 75 mg on a breastfed infant or on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Nurtec ODT and any potential adverse effects on the breastfed infant from Nurtec ODT or from the underlying maternal condition¹
References:Nurtec ODT. Package insert. Pfizer Inc.Blair HA. Rimegepant: a review in the acute treatment and preventive treatment of migraine. CNS Drugs. 2023;37(3):255-265. Published correction appears in CNS Drugs. 2023;37(7):661.Croop R, Lipton RB, Kudrow D, et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial. Lancet. 2021;397(10268):51-60. 
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INDICATIONSNurtec ODT is indicated in adults for the:
  • acute treatment of migraine with or without aura
  • preventive treatment of episodic migraine
Please click here for full Prescribing Information.
Important Safety Information Contraindications: Hypersensitivity to Nurtec ODT or any of its components. Warnings and Precautions Hypersensitivity Reactions: If a serious hypersensitivity reaction occurs, discontinue Nurtec ODT and initiate appropriate therapy. Serious hypersensitivity reactions have included anaphylaxis, dyspnea, and rash and can occur days after administration. Hypertension: Development of hypertension and worsening of pre-existing hypertension have been reported following the use of CGRP antagonists, including Nurtec ODT, in the postmarketing setting.Monitor patients for new-onset hypertension or worsening of pre-existing hypertension and consider whether discontinuation is warranted. Raynaud’s Phenomenon: Development of Raynaud’s phenomenon and recurrence or worsening of pre-existing Raynaud’s phenomenon have been reported in the postmarketing setting following the use of CGRP antagonists, including Nurtec ODT.If signs or symptoms of Raynaud’s phenomenon develop, discontinue Nurtec ODT. Patients should be evaluated by a healthcare provider if symptoms do not resolve. Patients with a history of Raynaud’s phenomenon should be monitored for and informed about the possibility of worsening or recurrence of signs and symptoms. Adverse Reactions: The most common adverse reactions for Nurtec ODT vs placebo were nausea (2.7% vs 0.8%) and abdominal pain/dyspepsia (2.4% vs 0.8%). Drug Interactions: Avoid concomitant administration of Nurtec ODT with strong inhibitors of CYP3A4 or strong or moderate inducers of CYP3A. Avoid another dose of Nurtec ODT within 48 hours when it is administered with moderate inhibitors of CYP3A4 or potent inhibitors of P-gp. Use in Specific Populations: Pregnancy: It is not known if Nurtec ODT can harm an unborn baby.

Lactation: The transfer of rimegepant into breast milk is low (<1%). Hepatic impairment: Avoid use of Nurtec ODT in persons with severe hepatic impairment. Renal impairment: Avoid use in patients with end-stage renal disease.

IndicationsNurtec ODT is indicated in adults for the:
  • acute treatment of migraine with or without aura
  • preventive treatment of episodic migraine
Please click here for full Prescribing Information.
Help your patients get started with Nurtec ODT
Ordering samples

For your patients with migraine, providing samples can be a great way to have them get started with their Nurtec ODT treatment. Follow the link below to order.
 


Please be aware that your eligibility to order Nurtec ODT samples on PfizerPro is determined by your
experience prescribing Nurtec ODT within the last 12 months.

Quarterly allocation

If you do not see Nurtec ODT on your sample list, come back later and try again. It may not have you on the list because it doesn’t have your history established or your quarterly allocation may have been exhausted—in both cases, the system will update.
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